Description

4-(3-Fluoro-4-Methylphenyl)Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and functional materials, where its unique substitution pattern introduces valuable electronic and steric properties. Pharmaceutical researchers, agrochemical developers, and material scientists need this precise chemical scaffold to create novel compounds with targeted biological activity or specific physical characteristics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atom enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, contributing to the molecular core of liquid crystals and organic light-emitting diode (OLED) components.
• Polymer Chemistry: Incorporated as a monomer or modifier to impart specific thermal, optical, or chemical resistance properties to high-performance polymers.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reaction pathways and creating libraries of fluorinated compounds for screening.
• Coordination Chemistry Ligand: The nitrile and aryl fluoride groups can act as ligands or precursors to ligands for metal-organic frameworks (MOFs) and catalysts.

Basic Information

Item	Detail
Product Name	4-(3-Fluoro-4-Methylphenyl)Benzonitrile
CAS No.	1352318-56-9
Molecular Formula	C14H10FN
Molecular Weight	211.24 g/mol
Synonyms	4-(3-Fluoro-4-methylphenyl)benzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 3'-fluoro-4'-methyl-; 3'-Fluoro-4'-methyl-[1,1'-biphenyl]-4-carbonitrile; 4-Cyano-3'-fluoro-4'-methylbiphenyl; 4-(3-Fluoro-4-methylphenyl)phenyl cyanide; p-(3-Fluoro-p-tolyl)benzonitrile; (3-Fluoro-4-methylphenyl)phenylacetonitrile precursor
EINECS	Contact for details

Quality Control

Our 4-(3-Fluoro-4-Methylphenyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.