Description

2-(3-Chloro-4-Fluorophenyl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its benzonitrile core with chloro and fluoro substituents. This compound is critical for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and manufacturers in the global pharmaceutical, agrochemical, and specialty chemical industries for developing new drug candidates and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drugs, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Serves as a precursor in the development of new herbicides and pesticides with specific activity profiles.
• Material Science: Used in the research and production of advanced organic electronic materials and liquid crystals.
• Chemical Synthesis: Acts as a versatile synthon for introducing the (3-chloro-4-fluorophenyl) moiety into more complex molecular structures in fine chemical production.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	2-(3-Chloro-4-Fluorophenyl)Benzonitrile
CAS No.	1352318-35-4
Molecular Formula	C₁₃H₇ClFN
Molecular Weight	231.65 g/mol
Synonyms	2-(3-Chloro-4-fluorophenyl)benzonitrile; [1,1'-Biphenyl]-2-carbonitrile, 3'-chloro-4'-fluoro-; 3'-Chloro-4'-fluoro-[1,1'-biphenyl]-2-carbonitrile; 2-(3-Chloro-4-fluorophenyl)phenyl cyanide; 3-Chloro-4-fluoro-2-cyanobiphenyl
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Chloro-4-Fluorophenyl)Benzonitrile is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure compliance with exacting purity standards suitable for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.