Description

2-(3-Chloro-5-Fluorophenyl)Benzonitrile is a high-purity fluorinated aromatic nitrile building block. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, enabling the introduction of specific halogenated aryl motifs. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require halogenated aromatic structures.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional organic materials due to its rigid, substituted biphenyl core.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Negishi, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Biology Probes: Utilized in the synthesis of fluorescent tags and molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	2-(3-Chloro-5-Fluorophenyl)Benzonitrile
CAS No.	1352318-29-6
Molecular Formula	C13H7ClFN
Molecular Weight	231.65 g/mol
Synonyms	2-(3-Chloro-5-fluorophenyl)benzonitrile; [1,1'-Biphenyl]-2-carbonitrile, 3'-chloro-5'-fluoro-; 3'-Chloro-5'-fluoro-[1,1'-biphenyl]-2-carbonitrile; 2-(3-Chloro-5-fluorophenyl)phenyl cyanide; 3-Chloro-5-fluoro-2-cyanobiphenyl; 2-Cyano-3'-chloro-5'-fluorobiphenyl
EINECS	Contact for details

Quality Control

Our 2-(3-Chloro-5-Fluorophenyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) with lot-specific data is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.