Description

4-Acetyl-3-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a nitrile and an acetyl group on a fluorinated benzene ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the discovery and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, CNS agents, and anti-inflammatory compounds.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science: Used in the research and development of advanced polymers, liquid crystals, and organic electronic materials due to its aromatic and polar functional groups.
• Chemical Synthesis: Acts as a versatile building block for further functionalization, including hydrolysis, reduction, and nucleophilic substitution reactions, to create diverse chemical libraries.

Basic Information

Product Name	4-Acetyl-3-Fluorobenzonitrile
CAS No.	1352144-78-5
Molecular Formula	C9H6FNO
Molecular Weight	163.15 g/mol
Synonyms	3-Fluoro-4-acetylbenzonitrile; 1-(4-Cyano-2-fluorophenyl)ethanone; 4-Cyano-2-fluoroacetophenone; 2-Fluoro-4-cyanobenzeneacetyl; 4-Acetyl-3-fluorophenyl cyanide; Ethanone, 1-(4-cyano-2-fluorophenyl)-; 4-Acetyl-3-fluorobenzene carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Acetyl-3-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Custom purity grades, including research and development (R&D) and kilogram-lab scale, are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.