Description

3,4-Dichloro-5-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its core value lies in its versatile halogen-substituted structure, which serves as a critical precursor for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Serves as a crucial precursor in the development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the dichloro-fluorobenzonitrile scaffold.
• Liquid Crystal & OLED Material Research: Used in the synthesis of fluorinated aromatic cores for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of reactive halogen atoms, enabling rapid diversification of molecular libraries.
• Functional Polymer Monomer: Employed as a specialty monomer to introduce fluorine and nitrile functionality into high-performance polymers, enhancing their thermal stability and chemical resistance.

Basic Information

Product Name	3,4-Dichloro-5-Fluorobenzonitrile
CAS No.	1349719-19-2
Molecular Formula	C7H2Cl2FN
Molecular Weight	190.00 g/mol
Synonyms	5-Fluoro-3,4-dichlorobenzonitrile; 3,4-Dichloro-5-fluorobenzene carbonitrile; 2,3-Dichloro-4-cyanobenzene fluoride; Benzonitrile, 3,4-dichloro-5-fluoro-; 3,4-Dichloro-5-fluorophenyl cyanide; 4-Cyano-2,3-dichlorofluorobenzene
EINECS	Contact for details

Quality Control

Our 3,4-Dichloro-5-Fluorobenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can provide material tailored to meet specific customer specifications and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored in amber glass or opaque containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.