Description

3,5-Difluoro-4-(Oxetan-3-Yloxy)Benzonitrile is a high-value, multi-functional chemical intermediate featuring a benzonitrile core substituted with fluorine atoms and an oxetane ether linkage. This unique molecular architecture makes it a critical building block for the synthesis of advanced pharmaceutical compounds and agrochemicals, where its structural motifs are leveraged to modulate biological activity and physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel small-molecule drugs, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the design and production of next-generation herbicides and fungicides, where the difluoro and oxetane groups enhance efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for constructing polarizable aromatic cores in electronic display and lighting materials.
• Polymer Modification: Incorporated as a functional monomer to introduce fluorine and ether groups into specialty polymers, improving chemical resistance and surface properties.
• Cross-Coupling Reactions: The benzonitrile and aryl fluoride moieties make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	3,5-Difluoro-4-(Oxetan-3-Yloxy)Benzonitrile
CAS No.	1349718-43-9
Molecular Formula	C10H7F2NO2
Molecular Weight	211.16 g/mol
Synonyms	4-(Oxetan-3-yloxy)-3,5-difluorobenzonitrile; 3,5-Difluoro-4-(3-oxetanyloxy)benzonitrile; Benzonitrile, 3,5-difluoro-4-(3-oxetanyloxy)-; 1349718-43-9; 3-Oxetanyl 3,5-difluoro-4-cyanophenyl ether
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluoro-4-(Oxetan-3-Yloxy)Benzonitrile is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.