Description

4-Bromo-3-Fluoro-2-Methylbenzonitrile is a high-purity, multi-functional halogenated aromatic nitrile building block. This compound is valued for its unique substitution pattern, which makes it a critical intermediate in advanced organic synthesis, particularly for constructing complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a precursor for functionalized organic materials, including liquid crystals and organic semiconductors.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination due to the reactive bromine atom.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific halogenated benzonitrile motifs.

Basic Information

Product Name	4-Bromo-3-Fluoro-2-Methylbenzonitrile
CAS No.	1349716-12-6
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	2-Methyl-4-bromo-3-fluorobenzonitrile; 3-Fluoro-4-bromo-2-methylbenzonitrile; Benzonitrile, 4-bromo-3-fluoro-2-methyl-; 4-Bromo-3-fluoro-o-tolunitrile; 2-Cyano-5-bromo-6-fluorotoluene
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluoro-2-Methylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.