Description

3-Bromo-4,5-Difluorobenzonitrile is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitrile substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores to modulate bioavailability and receptor binding.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the difluoro and bromo substituents contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings, enabling rapid diversification of chemical libraries.
• Fluorine Chemistry Studies: Utilized in academic and industrial R&D to study the effects of fluorine substitution on molecular properties and reaction pathways.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands and organocatalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	3-Bromo-4,5-Difluorobenzonitrile
CAS No.	1349715-72-5
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	3-Bromo-4,5-difluorobenzonitrile; 4,5-Difluoro-3-bromobenzonitrile; Benzonitrile, 3-bromo-4,5-difluoro-; 3-Bromo-4,5-difluorophenyl cyanide; 2-Bromo-4,5-difluorobenzonitrile (alternate numbering); 1349715-72-5; BDFBN (abbreviation)
EINECS	Contact for details

Quality Control

Our 3-Bromo-4,5-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP and ISO standards for pharmaceutical and industrial applications, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.