Description

Tos-Peg9-T-Butyl Ester CAS NO 1345337-28-1 is a specialized, high-purity PEGylated tosylate derivative designed for advanced organic synthesis and bioconjugation. This compound is engineered to provide a reactive tosylate leaving group coupled with a hydrophilic, non-immunogenic polyethylene glycol (PEG) spacer, enabling controlled functionalization of biomolecules and polymers. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors seeking to improve solubility, stability, and pharmacokinetic properties of their products.

Application

• Pharmaceutical Intermediates: Key reagent for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• PEGylation Chemistry: Used to introduce a defined-length, monodisperse PEG chain onto drugs, peptides, or proteins to enhance circulation time and reduce immunogenicity.
• Polymer Modification: Functionalizes polymer backbones to create amphiphilic block copolymers for drug delivery systems like micelles and hydrogels.
• Surface Functionalization: Enables the covalent attachment of bioactive molecules to nanoparticles, biosensors, and diagnostic assay substrates.
• Crosslinking Agent: Serves as a heterobifunctional linker in the preparation of biomaterial scaffolds and polymer networks.
• Prodrug Synthesis: Facilitates the creation of cleavable prodrug linkages for controlled drug release applications.

Basic Information

Product Name	Tos-Peg9-T-Butyl Ester
CAS No.	1345337-28-1
Molecular Formula	C31H64O13S
Molecular Weight	676.9 g/mol
Synonyms	tert-Butyl-PEG9-tosylate; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl 4-methylbenzenesulfonate; PEG9-t-Butyl Tosylate; Tos-PEG9-OtBu; 4-Methylbenzenesulfonic acid 3,6,9,12,15,18,21,24,27-nonaoxa-2,28-octacosanediylester; tert-Butoxy-nonaethylene glycol p-toluenesulfonate; Monotosylate of tert-butyl-PEG9-alcohol
EINECS	Contact for details

Quality Control

Our Tos-Peg9-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and GMP-grade applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.