Description

Pregna-1,4-Diene-3,20-Dione, 11,21,21-Trihydroxy-6-Methyl-, (6α,11β)- is a high-purity synthetic steroid derivative, specifically a methylated and trihydroxylated pregnadiene dione. This compound is valued for its role as a critical pharmaceutical intermediate in the synthesis of advanced corticosteroid and other therapeutic agents. It is primarily required by R&D laboratories and manufacturing facilities in the pharmaceutical and fine chemical sectors for developing novel drug candidates and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent corticosteroid drugs and other steroid-based therapeutics.
• Research & Development: Used in academic and industrial research for studying steroid metabolism, receptor binding, and biological activity.
• API Synthesis: Serves as a precursor in the multi-step manufacturing process of complex Active Pharmaceutical Ingredients (APIs).
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Utilized in biochemical assays to investigate enzyme inhibition and hormonal pathways.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione, 11,21,21-Trihydroxy-6-Methyl-, (6α,11β)-
CAS No.	1338549-01-1
Molecular Formula	C22H30O5
Molecular Weight	374.47 g/mol
Synonyms	6α-Methyl-11β,21-dihydroxypregna-1,4-diene-3,20-dione; 6α-Methylprednisolone 21-alcohol; 11β,21-Dihydroxy-6α-methylpregna-1,4-diene-3,20-dione; 6α-Methyl-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione; 6-Methylprednisolone; 6α-Methyl-δ1-hydrocortisone; 11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione (alternate numbering)
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 11,21,21-Trihydroxy-6-Methyl-, (6α,11β)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade specifications suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.