Description

3-[4-(Trifluoromethoxy)Phenyl]Benzonitrile is a high-value, multi-functional aromatic nitrile building block featuring a trifluoromethoxy substituent. This compound is critical for advanced organic synthesis, offering a unique combination of electronic and steric properties that enable the development of novel materials and active pharmaceutical ingredients. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for electron-transport materials, host materials, and polarizers in display technologies.
• Polymer & Resin Modifier: Incorporated into high-performance polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Organic Ligand Precursor: Utilized in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile reagent for method development and exploring new chemical spaces in academic and industrial laboratories.

Basic Information

Product Name	3-[4-(Trifluoromethoxy)Phenyl]Benzonitrile
CAS No.	1334721-50-4
Molecular Formula	C14H8F3NO
Molecular Weight	263.22 g/mol
Synonyms	3-[4-(Trifluoromethoxy)phenyl]benzonitrile; [1,1'-Biphenyl]-3-carbonitrile, 4'-(trifluoromethoxy)-; 4'-(Trifluoromethoxy)[1,1'-biphenyl]-3-carbonitrile; 3-(4-Trifluoromethoxyphenyl)benzonitrile; 3-(4-(Trifluoromethoxy)phenyl)benzonitrile; 3-(p-Trifluoromethoxyphenyl)benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-[4-(Trifluoromethoxy)Phenyl]Benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and MS is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.