Description

1-Bromo-3-Chloro-2-Fluoro-5-Nitrobenzene is a high-purity, multi-substituted aromatic building block of significant importance in advanced organic synthesis. Its unique halogen and nitro substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring specific halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the nitro and halogen groups are essential for bioactivity.
• Material Science Research: Acts as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Chemical Biology & Proteomics: Employed in the development of molecular probes, tags, and linkers for studying biological systems.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex, high-performance dyes and pigments where halogen and nitro groups influence color and stability.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form biaryl structures.

Basic Information

Product Name	1-Bromo-3-Chloro-2-Fluoro-5-Nitrobenzene
CAS No.	1330583-70-4
Molecular Formula	C6H2BrClFNO2
Molecular Weight	269.44 g/mol
Synonyms	2-Bromo-6-Chloro-3-Fluoronitrobenzene; 3-Chloro-2-fluoro-5-nitro-1-bromobenzene; 1-Bromo-3-chloro-2-fluoro-5-nitro-benzene; Benzene, 1-bromo-3-chloro-2-fluoro-5-nitro-; 5-Nitro-1-bromo-3-chloro-2-fluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-2-Fluoro-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.