Description

2-Fluoro-4-(4,4,4-trifluorobutoxy)benzonitrile is a high-value fluorinated aromatic intermediate with a unique combination of a nitrile group and a fluoroalkoxy side chain. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) where its specific fluorine substitution pattern imparts desirable properties like metabolic stability and lipophilicity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Polymer Modification: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Electronics: Acts as a starting material for electron-transport materials or semiconductors in OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex aromatic ethers in academic and industrial labs.

Basic Information

Product Name	2-Fluoro-4-(4,4,4-trifluorobutoxy)benzonitrile
CAS No.	1325296-10-3
Molecular Formula	C11H9F4NO
Molecular Weight	247.19 g/mol
Synonyms	4-(4,4,4-Trifluorobutoxy)-2-fluorobenzonitrile; 2-Fluoro-4-(4,4,4-trifluorobutoxy)benzonitrile; Benzonitrile, 2-fluoro-4-(4,4,4-trifluorobutoxy)-; 1325296-10-3; 2-Fluoro-4-(4,4,4-trifluorobutoxy)phenyl cyanide; 4-(4,4,4-Trifluorobutoxy)-2-fluorophenyl cyanide; 2-Fluoro-4-(ω,ω,ω-trifluorobutoxy)benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(4,4,4-trifluorobutoxy)benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.