Description

4-Fluoro-2-(Trifluoromethoxy)Benzonitrile is a high-value fluorinated aromatic nitrile building block, essential for introducing specific steric and electronic properties into advanced molecular architectures. Its unique trifluoromethoxy and fluorine substituents make it a critical intermediate for developing novel compounds with enhanced metabolic stability and lipophilicity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and stability.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and low surface energy properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new reactions in cross-coupling, cyanation, and fluorination chemistry.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use as a precursor for radiolabeled compounds used in medical imaging diagnostics.

Basic Information

Product Name	4-Fluoro-2-(Trifluoromethoxy)Benzonitrile
CAS No.	1323966-32-0
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	2-(Trifluoromethoxy)-4-fluorobenzonitrile; 4-Fluoro-2-(trifluoromethoxy)benzonitrile; 4-Fluoro-α,α,α-trifluoro-o-tolunitrile; 2-Cyano-5-fluoro-1-(trifluoromethoxy)benzene; 1-Fluoro-3-cyano-4-(trifluoromethoxy)benzene; Benzonitrile, 4-fluoro-2-(trifluoromethoxy)-; 4-Fluoro-2-trifluoromethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.