Description

4-Chloro-3-Ethoxy-2-Fluorobenzyl Bromide, 97% is a high-purity, multi-functional halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its precise molecular architecture, which enables the introduction of key functional groups for constructing complex molecules with high selectivity. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine and chlorine substituents for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for creating advanced organic electronic materials, including charge-transport layers and emissive compounds.
• Cross-Coupling Reactions: The benzyl bromide moiety acts as an effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Functional Group Transformation: Utilized for nucleophilic substitution reactions to introduce various amines, thiols, and other nucleophiles, enabling rapid diversification of molecular scaffolds.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes (ABPs) and affinity tags for studying enzyme function and protein labeling.

Basic Information

Product Name	4-Chloro-3-Ethoxy-2-Fluorobenzyl Bromide, 97%
CAS No.	1323966-30-8
Molecular Formula	C9H9BrClFO
Molecular Weight	267.52 g/mol
Synonyms	1-(Bromomethyl)-4-chloro-3-ethoxy-2-fluorobenzene; 2-Fluoro-4-chloro-3-ethoxybenzyl bromide; (4-Chloro-3-ethoxy-2-fluorophenyl)methyl bromide; 4-Chloro-3-ethoxy-2-fluorobenzylbromide; 4-Chloro-3-ethoxy-2-fluorobenzyl bromide; 4-Chloro-3-ethoxy-2-fluorobenzyl bromide, 97%; Benzene, 1-(bromomethyl)-4-chloro-3-ethoxy-2-fluoro-; 1323966-30-8
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Ethoxy-2-Fluorobenzyl Bromide is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the specified 97% minimum assay. Certificates of Analysis (COA) detailing all test results are provided and available upon request, supporting compliance in GMP-aligned synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.