Description

2-Fluoro-5-Methyl-4-(Trifluoromethyl)Phenylacetonitrile, 97% is a high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and cyano functional groups, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Functional Material Development: Employed in the synthesis of specialty polymers, coatings, and advanced materials requiring specific fluorinated aromatic architectures.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2-Fluoro-5-Methyl-4-(Trifluoromethyl)Phenylacetonitrile, 97%
CAS No.	1323966-11-5
Molecular Formula	C10H7F4N
Molecular Weight	217.16 g/mol
Synonyms	2-Fluoro-5-methyl-4-(trifluoromethyl)benzyl cyanide; [2-Fluoro-5-methyl-4-(trifluoromethyl)phenyl]acetonitrile; 4-(Trifluoromethyl)-2-fluoro-5-methylphenylacetonitrile; α-(2-Fluoro-5-methyl-4-(trifluoromethyl)phenyl)acetonitrile; 2-Fluoro-α-cyano-5-methyl-4-(trifluoromethyl)toluene; (2-Fluoro-5-methyl-4-(trifluoromethyl)phenyl)ethanenitrile; FTMPA (common abbreviation)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Methyl-4-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure the 97% minimum purity and identity are met. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.