Description

(S)-(-)-5-Fluorowillardiine (Hydrochloride) is a high-purity, non-proteinogenic amino acid derivative and a potent, selective agonist for glutamate receptor subtypes. This compound is a critical research-grade chemical, valued for its role in advanced neuropharmacological studies and drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience and receptor characterization.

Application

• Neuroscience Research: As a selective agonist for kainate and AMPA subtypes of ionotropic glutamate receptors (GluK1, GluA1-4).
• Pharmacological Studies: Used in receptor binding assays, electrophysiology experiments, and functional characterization of neural pathways.
• Drug Discovery & Development: Serves as a key reference standard and pharmacophore in the design of novel neuroactive compounds targeting neurological disorders.
• Biochemical Research: Employed in studies of excitatory synaptic transmission, neurotoxicity, and mechanisms of neuronal plasticity.
• Academic & Institutional R&D: A fundamental tool for graduate-level and post-doctoral research in molecular neurobiology and medicinal chemistry.

Basic Information

Product Name	(S)-(-)-5-Fluorowillardiine (Hydrochloride)
CAS No.	1321546-70-6
Molecular Formula	C7H8FN3O4 • HCl
Molecular Weight	253.61 g/mol (Free base: 217.16)
Synonyms	(S)-5-Fluorowillardiine hydrochloride; (S)-5-Fluoro-1,2-dihydro-5H-imidazo[1,2-a]pyrrolo[3,4-d]pyrazine-5,7(6H)-dione hydrochloride; 5-Fluoro-L-willardiine hydrochloride; Fluorowillardiine HCl; (S)-(-)-5-F-Willardiine HCl; GluK1/AMPA receptor agonist; Willardiine derivative, fluorinated
EINECS	Contact for details

Quality Control

Our (S)-(-)-5-Fluorowillardiine (Hydrochloride) is manufactured under strict quality control protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.