Description

Fulvestrant (ICI 182780) S Enantiomer is the biologically active stereoisomer of a potent, pure antiestrogen. This compound is a critical reference standard and active pharmaceutical ingredient (API) intermediate used in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on developing novel endocrine therapies for hormone-receptor-positive cancers, particularly breast cancer.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity calibration standard for analytical method development and quality control in API manufacturing.
• Biomedical Research: Used as a selective estrogen receptor downregulator (SERD) in preclinical studies to investigate estrogen receptor signaling pathways and mechanisms of action.
• Drug Discovery & Development: A key intermediate and pharmacological tool compound in the R&D of new-generation hormone therapies for oncology.
• Academic Research: Employed in university and institutional labs for fundamental studies in endocrinology, cancer biology, and molecular pharmacology.
• Process Chemistry: Used in the development and optimization of synthetic routes for steroidal active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fulvestrant (ICI 182780) S Enantiomer
CAS No.	1316849-17-8
Molecular Formula	C32H47F5O3S
Molecular Weight	606.78 g/mol
Synonyms	Fulvestrant S-Enantiomer; ICI-182780 S-Enantiomer; (7R,8S,9S,13S,14S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; Faslodex Impurity; ZD9238 S-Enantiomer; Estrogen Receptor Antagonist ICI 182780 S-Form
EINECS	Contact for details

Quality Control

Our Fulvestrant S Enantiomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and chromatographic profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-Enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.