Description

Fmoc-α-Me-D-Phe(2-F)-Oh is a specialized, non-natural amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a modified phenylalanine residue with a fluorine substituent and an α-methyl group in the D-configuration. It is essential for researchers and manufacturers in pharmaceutical R&D and biotechnology who are developing novel peptide-based therapeutics, diagnostics, and research tools. The structural modifications offer enhanced metabolic stability, altered receptor binding affinity, and improved pharmacokinetic properties to the target peptides.

Application

• Pharmaceutical Research & Development: A key intermediate for synthesizing complex peptide drug candidates, including antimicrobial peptides, hormone analogs, and targeted cancer therapies.
• Peptidomimetic Design: Used to create peptide mimics where the α-methyl-D-2-fluorophenylalanine moiety introduces conformational constraints and enhances biological activity.
• Chemical Biology & Proteomics: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• API (Active Pharmaceutical Ingredient) Synthesis: Serves as a building block in the multi-step synthesis of peptide-based active ingredients under current Good Manufacturing Practice (cGMP) standards.
• Diagnostic Reagent Production: Utilized in the manufacture of peptide components for in-vitro diagnostic assays and imaging probes.

Basic Information

Product Name	Fmoc-α-Me-D-Phe(2-F)-Oh
CAS No.	1315449-93-4
Molecular Formula	C26H24FNO4
Molecular Weight	433.47 g/mol
Synonyms	Fmoc-α-methyl-D-2-fluorophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-2-fluoro-D-phenylalanine; Fmoc-D-α-Me-2-F-Phe-OH; N-Fmoc-α-methyl-2-fluoro-D-phenylalanine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-3-(2-fluorophenyl)propanoic acid; Fmoc-α-Me-2-F-D-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-D-Phe(2-F)-Oh is manufactured and tested to meet the stringent requirements of advanced peptide synthesis. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. We provide comprehensive Certificates of Analysis (COA) detailing identity, assay, and impurity profiles, ensuring traceability and compliance with research and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.