Description

N,N'-Diboc-2-Amino-6-Fluorobenzonitrile is a high-purity, protected amino nitrile building block designed for advanced organic synthesis. This compound is critical for researchers and process chemists requiring precise molecular architecture in complex multi-step reactions. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly where the introduction of a fluorine atom and a protected amine group is strategically important.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in constructing advanced intermediates for novel pesticides and herbicides, leveraging the bioactivity-modifying properties of the fluorine substituent.
• Peptidomimetics & PROTACs: Serves as a versatile building block for creating peptide analogs and Proteolysis Targeting Chimeras (PROTACs) due to its protected amine functionality.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials that require fluorinated aromatic units.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in research applications to study biological pathways.
• Scale-up Process Development: Suitable for process optimization and pilot-scale synthesis under current Good Manufacturing Practice (cGMP) guidelines for clinical trial material production.

Basic Information

Product Name	N,N'-Diboc-2-Amino-6-Fluorobenzonitrile
CAS No.	1313712-57-0
Molecular Formula	C₁₈H₂₄FN₃O₄
Molecular Weight	365.40 g/mol
Synonyms	2-Amino-6-fluorobenzonitrile, N,N'-bis-Boc protected; 2-((tert-Butoxycarbonyl)amino)-6-fluoro-1-((tert-butoxycarbonyl)imino)benzonitrile; 1,3-Di-tert-butyl 2-(2-cyano-3-fluorophenyl)imidodicarbonate; 6-Fluoro-2-[(2-methylpropan-2-yl)oxycarbonylamino]benzonitrile; Di-Boc-2-amino-6-fluorobenzonitrile; N,N-Bis-Boc-2-amino-6-fluorobenzonitrile; 2-Amino-6-fluorobenzonitrile Di-Boc derivative
EINECS	Contact for details

Quality Control

Our N,N'-Diboc-2-Amino-6-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.