Description

3,5-Difluoropyridine-4-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is critically needed by R&D and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the difluoropyridine moiety into drug candidates, particularly in kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the difluoropyridine unit can enhance biological activity and metabolic stability.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials through palladium-catalyzed coupling reactions.
• Chemical Research & Development: Employed in academic and industrial labs for method development and the synthesis of complex, fluorinated heterocyclic compounds for various applications.
• Ligand & Catalyst Design: Utilized to construct novel bidentate or tridentate ligands for metal catalysis, leveraging the boronic ester's reactivity and the pyridine's coordinating ability.

Basic Information

Product Name	3,5-Difluoropyridine-4-Boronic Acid Pinacol Ester
CAS No.	1310404-59-1
Molecular Formula	C11H14BF2NO2
Molecular Weight	241.05 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(3,5-difluoropyridin-4-yl)-1,3,2-dioxaborolane; 3,5-Difluoropyridine-4-boronic acid pinacol ester; (3,5-Difluoropyridin-4-yl)boronic acid pinacol ester; 3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-difluoropyridine
EINECS	Contact for details

Quality Control

Our 3,5-Difluoropyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.