Description

1-Bromomethyl-2-Chloro-5-Fluoro-4-Nitro-Benzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the precise introduction of bromomethyl, chloro, fluoro, and nitro substituents in a single molecule. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Serves as a critical building block for developing new herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional handles.
• Cross-Coupling Reactions: The bromomethyl group is an excellent electrophile for nucleophilic substitution, while the aromatic halides facilitate Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology & Proteomics: Employed as a reagent for protein labeling, bioconjugation, and the synthesis of molecular probes and inhibitors.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing complex, halogen-substituted dyes and pigments with enhanced light-fastness and color properties.

Basic Information

Product Name	1-Bromomethyl-2-Chloro-5-Fluoro-4-Nitro-Benzene
CAS No.	1299488-14-4
Molecular Formula	C7H4BrClFNO2
Molecular Weight	268.47 g/mol
Synonyms	2-Chloro-5-fluoro-4-nitrobenzyl bromide; 2-Chloro-5-fluoro-4-nitrobenzyl bromide; Benzene, 1-(bromomethyl)-2-chloro-5-fluoro-4-nitro-; 2-Chloro-5-fluoro-4-nitrobenzyl bromide; (2-Chloro-5-fluoro-4-nitrophenyl)methyl bromide; 4-Nitro-2-chloro-5-fluorobenzyl bromide; α-Bromo-2-chloro-5-fluoro-4-nitrotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromomethyl-2-Chloro-5-Fluoro-4-Nitro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.