Description

Methyl 1-Benzyl-3-Fluoropyrrolidine-3-Carboxylate CAS NO 1279669-60-1 is a high-purity fluorinated pyrrolidine derivative, a crucial advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which incorporates both a fluorine atom and a benzyl-protected amine, making it a versatile building block for constructing complex, biologically active molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis teams focused on developing new drug candidates, particularly in the areas of central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Medicinal Chemistry Building Block: Used to introduce the fluorinated pyrrolidine moiety into lead compounds to modulate pharmacokinetic properties like metabolic stability and bioavailability.
• Protease Inhibitor Synthesis: Serves as a core structure in the synthesis of inhibitors targeting various proteases, which are relevant in virology and oncology research.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Agrochemical Research: Used as an intermediate in the discovery of new crop protection agents with enhanced activity.
• Chemical Biology Probe Synthesis: Facilitates the creation of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	Methyl 1-Benzyl-3-Fluoropyrrolidine-3-Carboxylate
CAS No.	1279669-60-1
Molecular Formula	C13H16FNO2
Molecular Weight	237.27 g/mol
Synonyms	1-Benzyl-3-fluoro-3-pyrrolidinecarboxylic acid methyl ester; Methyl 1-benzyl-3-fluoropyrrolidine-3-carboxylate; 3-Fluoro-1-benzylpyrrolidine-3-carboxylic acid methyl ester; 1-Benzyl-3-fluoropyrrolidine-3-carboxylic acid methyl ester; 3-Fluoro-1-(phenylmethyl)-3-pyrrolidinecarboxylic acid methyl ester; Methyl 3-fluoro-1-(phenylmethyl)pyrrolidine-3-carboxylate; 1279669-60-1
EINECS	Contact for details

Quality Control

Our production of Methyl 1-Benzyl-3-Fluoropyrrolidine-3-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive pharmaceutical applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.