Description

(2S,4S)-1-tert-Butyl 2-Methyl 4-Fluoro-5-Oxopyrrolidine-1,2-Dicarboxylate is a high-purity, stereochemically defined fluorinated pyrrolidinone derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a chiral, functionalized scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), particularly in the areas of protease inhibitors and other therapeutic agents where the fluorinated pyrrolidinone motif is pharmacologically relevant.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, especially protease inhibitors.
• Chiral Synthesis: Utilized in asymmetric synthesis to introduce defined stereocenters into complex molecular frameworks.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Peptidomimetic Development: Core structure for creating peptidomimetics that mimic natural peptides but with enhanced metabolic stability.
• Chemical Biology Probes: Used in the development of labeled compounds and probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules in late-stage R&D.

Basic Information

Item	Detail
Product Name	(2S,4S)-1-tert-Butyl 2-Methyl 4-Fluoro-5-Oxopyrrolidine-1,2-Dicarboxylate
CAS No.	1268729-74-3
Molecular Formula	C12H18FNO5
Molecular Weight	275.28 g/mol
Synonyms	1-Boc-4-Fluoro-5-oxopyrrolidine-2-carboxylic acid methyl ester (2S,4S)-; (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-5-oxopyrrolidine-2-carboxylic acid methyl ester; (2S,4S)-1-Boc-4-fluoro-5-oxopyrrolidine-2-carboxylic acid methyl ester; Methyl (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoro-5-oxopyrrolidine-2-carboxylate; (2S,4S)-4-Fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]-5-oxopyrrolidine-2-carboxylic acid methyl ester; 1-tert-Butyl 2-methyl (2S,4S)-4-fluoro-5-oxopyrrolidine-1,2-dicarboxylate; Fluoropyrrolidinone Boc-methyl ester
EINECS	Contact for details

Quality Control

Our (2S,4S)-1-tert-Butyl 2-Methyl 4-Fluoro-5-Oxopyrrolidine-1,2-Dicarboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.