Description

3-(3,5-Difluorophenyl)Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluorophenyl moiety is prized for its ability to modulate biological activity and improve metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries seeking to incorporate this specific fluorinated scaffold into novel molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorinated aromatic system enhances efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display and lighting applications.
• Organic Light-Emitting Diode (OLED) Intermediates: Employed in the synthesis of electron-transport or host materials for high-performance display technologies.
• Cross-Coupling Reactions: Functions as a versatile substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent for academic and industrial labs exploring new fluorination chemistry and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	3-(3,5-Difluorophenyl)Benzonitrile
CAS No.	1266996-50-2
Molecular Formula	C13H7F2N
Molecular Weight	215.20 g/mol
Synonyms	3-(3,5-Difluorophenyl)benzonitrile; [1,1'-Biphenyl]-3-carbonitrile, 3',5'-difluoro-; 3',5'-Difluoro-[1,1'-biphenyl]-3-carbonitrile; 3-(3,5-Difluorophenyl)phenyl cyanide; 3-Cyano-3',5'-difluorobiphenyl
EINECS	Contact for details

Quality Control

Our 3-(3,5-Difluorophenyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.