Description

2-Ethynyl-4-Fluoro-1-Nitrobenzene is a high-purity, multi-functional aromatic building block designed for advanced chemical synthesis. Its unique structure, featuring an ethynyl group, a fluorine atom, and a nitro group on a benzene ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anticancer drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Materials Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D for palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki) and click chemistry applications.
• Fluorine Chemistry: Acts as a valuable substrate for further fluorination or functional group transformation studies due to its activated aromatic system.

Basic Information

Product Name	2-Ethynyl-4-Fluoro-1-Nitrobenzene
CAS No.	1265623-60-6
Molecular Formula	C8H4FNO2
Molecular Weight	165.12 g/mol
Synonyms	4-Fluoro-2-ethynyl-1-nitrobenzene; 1-Fluoro-4-ethynyl-2-nitrobenzene; 2-Ethynyl-4-fluoronitrobenzene; 2-Nitro-5-fluoroethynylbenzene; 2-Ethynyl-4-fluoronitrobenzene; 4-Fluoro-2-(ethynyl)nitrobenzene; 2-Ethynyl-4-fluoro-1-nitro-benzene
EINECS	Contact for details

Quality Control

Every batch of 2-Ethynyl-4-Fluoro-1-Nitrobenzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' needs in regulated development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Related Substances (HPLC)	Total impurities < 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.