Description

5-Bromo-2,3-difluoro-1-nitrobenzene is a high-purity halogenated nitrobenzene derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro and nitro groups contribute to biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Buchwald-Hartwig) to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups allow for selective substitution, enabling the introduction of various amines, alkoxides, and thiols.
• Chemical Library Development: A valuable scaffold for creating diverse compound libraries in medicinal chemistry for high-throughput screening and hit-to-lead optimization.

Basic Information

Product Name	5-Bromo-2,3-difluoro-1-nitrobenzene
CAS No.	1261988-16-2
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	1-Bromo-2,3-difluoro-4-nitrobenzene; 2,3-Difluoro-5-bromonitrobenzene; 5-Bromo-2,3-difluoronitrobenzene; Benzene, 5-bromo-2,3-difluoro-1-nitro-; 4-Nitro-2,3-difluorobromobenzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,3-difluoro-1-nitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Standard quality verification includes HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support custom purity specifications for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark place.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.