Description

2-Fluoro-4'-Hydroxy-[1,1'-Biphenyl]-3-Carbonitrile is a high-purity, fluorinated biphenyl derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and critical pharmaceutical intermediate for constructing complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a core structure for creating fluorinated biphenyl-based molecules used in electronic displays and organic light-emitting diodes.
• Ligand & Catalyst Development: Utilized in organometallic chemistry to create specialized ligands for asymmetric catalysis and cross-coupling reactions.
• Polymer Modification: Acts as a monomer or functional additive to introduce fluorine and cyano groups into polymer backbones, altering material properties.
• Academic & Contract Research: Essential reagent for methodological studies in organic chemistry, including C-H activation and fluorination chemistry.

Basic Information

Product Name	2-Fluoro-4'-Hydroxy-[1,1'-Biphenyl]-3-Carbonitrile
CAS No.	1261951-45-4
Molecular Formula	C₁₃H₈FNO
Molecular Weight	213.21 g/mol
Synonyms	[1,1'-Biphenyl]-3-carbonitrile, 2-fluoro-4'-hydroxy-; 2-Fluoro-4'-hydroxybiphenyl-3-carbonitrile; 3-Cyano-2-fluoro-4'-hydroxybiphenyl; 4'-Hydroxy-2-fluorobiphenyl-3-carbonitrile; 2-Fluoro-4'-hydroxy-[1,1'-biphenyl]-3-carbonitrile; 2-Fluoro-4'-hydroxy-1,1'-biphenyl-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4'-Hydroxy-[1,1'-Biphenyl]-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.