Description

2-(2-(Difluoromethoxy)-6-Fluorophenyl)Acetonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring difluoromethoxy and fluoro substituents, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals that require fluorinated aromatic units for specific electronic or optical properties.
• Chemical Biology Probes: Utilized in the development of fluorinated probes and tags for studying biological mechanisms and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) serving the global life sciences market.

Basic Information

Product Name	2-(2-(Difluoromethoxy)-6-Fluorophenyl)Acetonitrile
CAS No.	1261862-28-5
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	2-(2-(Difluoromethoxy)-6-fluorophenyl)acetonitrile; (2-(Difluoromethoxy)-6-fluorophenyl)acetonitrile; 2-(2-(Difluoromethoxy)-6-fluorophenyl)ethanenitrile; α-Cyano-2-(difluoromethoxy)-6-fluorotoluene; 2-(Difluoromethoxy)-6-fluorobenzyl cyanide; 1261862-28-5; CAS 1261862-28-5
EINECS	Contact for details

Quality Control

Every batch of 2-(2-(Difluoromethoxy)-6-Fluorophenyl)Acetonitrile is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and ensure compliance with relevant ICH guidelines for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles via HPLC, GC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.