Description

2-Fluoro-3-Hydroxymethyl-Benzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a reactive nitrile group and a hydroxymethyl substituent on a fluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), leveraging the fluorine atom for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorobenzonitrile core is a common pharmacophore.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced polymers and liquid crystals, where its aromatic and polar functional groups contribute to material properties.
• Chemical Biology Probes: Utilized as a scaffold for developing fluorescent tags or molecular probes for studying biological systems.

Basic Information

Item	Detail
Product Name	2-Fluoro-3-Hydroxymethyl-Benzonitrile
CAS No.	1261861-91-9
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	2-Fluoro-3-(hydroxymethyl)benzonitrile; 3-Cyano-2-fluorobenzyl alcohol; (3-Cyano-2-fluorophenyl)methanol; Benzonitrile, 2-fluoro-3-(hydroxymethyl)-; 2-Fluoro-3-hydroxymethylbenzonitrile; 1261861-91-9; 2-Fluoro-3-(hydroxymethyl)phenyl cyanide
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-3-Hydroxymethyl-Benzonitrile adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting customer specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, guaranteeing traceability and compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.