Description

4-Bromo-2-(Difluoromethoxy)-1-Nitro-Benzene is a high-value, multi-functional aromatic building block characterized by its unique combination of bromo, difluoromethoxy, and nitro substituents. This compound is critical for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its structure enables precise molecular modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, due to the bioisosteric properties of the difluoromethoxy group.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the halogen and nitro groups are essential for biological activity.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations.
• Nucleophilic Aromatic Substitution: The nitro group ortho to the bromine activates the molecule for substitution reactions, useful for creating diverse chemical libraries.
• Fluorine Chemistry Studies: A valuable compound for investigating the effects of fluorine and fluorinated alkoxy groups on chemical reactivity and physical properties.

Basic Information

Product Name	4-Bromo-2-(Difluoromethoxy)-1-Nitro-Benzene
CAS No.	1261849-33-5
Molecular Formula	C7H4BrF2NO3
Molecular Weight	268.01 g/mol
Synonyms	1-Bromo-4-(difluoromethoxy)-2-nitrobenzene; 2-Nitro-4-bromophenyl difluoromethyl ether; 4-Bromo-2-(difluoromethoxy)nitrobenzene; 4-Bromo-1-(difluoromethoxy)-2-nitrobenzene; Benzene, 4-bromo-2-(difluoromethoxy)-1-nitro-; 1261849-33-5; 4-Bromo-2-difluoromethoxy-1-nitrobenzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Difluoromethoxy)-1-Nitro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.