Description

4-Fluoro-2-(Difluoromethyl)Benzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a benzonitrile core with strategically placed fluorine atoms, enabling precise modulation of electronic properties and lipophilicity in target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex intermediates, particularly in the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal compounds and electron-transport materials in organic light-emitting diodes (OLEDs) due to its electronic properties.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with tailored properties such as chemical resistance, thermal stability, and specific optical characteristics.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl and conjugated systems.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new fluorination methodologies and the effects of fluorine substitution.

Basic Information

Product Name	4-Fluoro-2-(Difluoromethyl)Benzonitrile
CAS No.	1261825-82-4
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	2-(Difluoromethyl)-4-fluorobenzonitrile; 4-Fluoro-2-(difluoromethyl)benzonitrile; 2-(Difluoromethyl)-4-fluorobenzene carbonitrile; 4-Fluoro-α,α-difluoro-o-tolunitrile; Benzonitrile, 4-fluoro-2-(difluoromethyl)-; 1261825-82-4; 4-Fluoro-2-difluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Difluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.