Description

4-(Difluoromethoxy)-3-Hydroxybenzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its distinct benzonitrile core with difluoromethoxy and hydroxyl substituents. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of oncology, neurology, and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging the difluoromethoxy group's influence on biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Investigated as a monomer or additive for the synthesis of high-performance polymers with specific optical or electronic properties.
• Life Science Research: Employed as a biochemical tool and probe in academic and industrial research for studying enzyme interactions and cellular processes.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Hydroxybenzonitrile
CAS No.	1261823-17-9
Molecular Formula	C8H5F2NO2
Molecular Weight	185.13 g/mol
Synonyms	3-Hydroxy-4-(difluoromethoxy)benzonitrile; 4-(Difluoromethoxy)-3-hydroxybenzonitrile; Benzonitrile, 4-(difluoromethoxy)-3-hydroxy-; 1261823-17-9
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethoxy)-3-Hydroxybenzonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency. Our products are suitable for research and development applications, with specifications tailored to client requirements. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.