Description

3-Bromo-4-Difluoromethoxy-Benzonitrile CAS NO 1261818-75-0 is a high-value, multi-functional aromatic nitrile building block designed for advanced chemical synthesis. Its unique structure, featuring bromine and difluoromethoxy substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to introduce specific halogenated and fluorinated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form new carbon-carbon bonds.
• Fluorine Chemistry Research: An important substrate for studying the effects of fluorine substitution and for developing new fluorination methodologies in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects requiring precise, high-purity halogenated intermediates.

Basic Information

Product Name	3-Bromo-4-Difluoromethoxy-Benzonitrile
CAS No.	1261818-75-0
Molecular Formula	C8H4BrF2NO
Molecular Weight	248.03 g/mol
Synonyms	4-(Difluoromethoxy)-3-bromobenzonitrile; 3-Bromo-4-(difluoromethoxy)benzonitrile; Benzonitrile, 3-bromo-4-(difluoromethoxy)-; 1261818-75-0; 3-Bromo-4-difluoromethoxybenzonitrile; 3-Br-4-(OCHF2)-C6H3-CN
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-Difluoromethoxy-Benzonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC Area %)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.