Description

Benzene, 2-Bromo-4-(Difluoromethyl)-1-Nitro- is a high-purity, multi-functional halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, difluoromethyl, and nitro substituents, makes it an indispensable intermediate for introducing specific functionalities into complex molecules. This compound is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoromethyl group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it a valuable substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro group facilitates substitution reactions, allowing for the introduction of amines, alkoxides, and other nucleophiles.
• Fluorine Chemistry Building Block: Essential for medicinal chemistry programs exploring the benefits of fluorine incorporation to modulate lipophilicity, bioavailability, and binding affinity.

Basic Information

Product Name	Benzene, 2-Bromo-4-(Difluoromethyl)-1-Nitro-
CAS No.	1261791-52-9
Molecular Formula	C7H4BrF2NO2
Molecular Weight	252.02 g/mol
Synonyms	2-Bromo-4-(difluoromethyl)-1-nitrobenzene; 1-Bromo-2-(difluoromethyl)-5-nitrobenzene; 2-Bromo-α,α-difluoro-4-nitrobenzyl; 4-Nitro-2-bromobenzylidene difluoride; 2-Bromo-4-(difluoromethyl)nitrobenzene; 5-Nitro-2-bromobenzylidene difluoride; 2-Bromo-4-difluoromethyl-1-nitrobenzene; 2-Bromo-4-difluoromethylnitrobenzene
EINECS	Contact for details

Quality Control

Our Benzene, 2-Bromo-4-(Difluoromethyl)-1-Nitro- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.