Description

2-Fluoro-1-Iodo-3-Nitrobenzene is a high-purity, multi-functional halogenated nitroaromatic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity profile, where the fluorine, iodine, and nitro groups offer distinct and orthogonal sites for selective functionalization. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated and iodinated active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the halogen atoms contribute to biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups allow for selective displacement with various nucleophiles, enabling rapid diversification of the benzene core.
• Chemical Biology & Diagnostics: Employed as a labeling reagent or probe precursor in bio-conjugation chemistry and diagnostic assay development.

Basic Information

Product Name	2-Fluoro-1-Iodo-3-Nitrobenzene
CAS No.	1261782-23-3
Molecular Formula	C6H3FINO2
Molecular Weight	266.99 g/mol
Synonyms	1-Fluoro-2-Iodo-3-Nitrobenzene; 3-Nitro-2-fluoroiodobenzene; 2-Fluoro-3-nitroiodobenzene; 2-Fluoro-3-nitro-1-iodobenzene; 1-Iodo-2-fluoro-3-nitrobenzene; Benzene, 2-fluoro-1-iodo-3-nitro-; (2-Fluoro-3-nitrophenyl)iodide
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-1-Iodo-3-Nitrobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.