Description

3-(Chloromethyl)-4-Fluorobenzonitrile is a versatile and high-value fluorinated aromatic building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its reactive chloromethyl and cyano groups enable targeted structural modifications. It is primarily sought after by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), advanced materials, and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The chloromethyl group facilitates further functionalization via Suzuki, Heck, or other palladium-catalyzed cross-coupling reactions.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: An essential raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global fine chemical market.

Basic Information

Product Name	3-(Chloromethyl)-4-Fluorobenzonitrile
CAS No.	1261780-05-5
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	4-Fluoro-3-(chloromethyl)benzonitrile; 4-Fluoro-3-chloromethylbenzonitrile; 3-Chloromethyl-4-fluorobenzonitrile; 2-Fluoro-5-(chloromethyl)benzonitrile; Benzonitrile, 3-(chloromethyl)-4-fluoro-; 1261780-05-5; 4-Fluoro-3-(chloromethyl)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 3-(Chloromethyl)-4-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials. Keep container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.