Description

3-Iodo-2-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic building block containing both iodine and trifluoromethyl substituents. This compound is critical for advanced organic synthesis, enabling the introduction of key functional groups and fluorinated motifs into target molecules. It is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Cross-Coupling Reactions: The iodine atom serves as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to construct complex biaryl and conjugated systems.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, where fluorine substitution improves electronic properties and stability.
• Radiolabeling Precursor: The iodine atom can be exchanged for radioactive iodine-125 or iodine-131, making it a candidate for creating radiolabeled tracers for diagnostic imaging and research.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique solubility, thermal stability, and chemical resistance properties.

Basic Information

Product Name	3-Iodo-2-(Trifluoromethyl)Benzonitrile
CAS No.	1261748-11-1
Molecular Formula	C8H3F3IN
Molecular Weight	312.97 g/mol
Synonyms	2-Cyano-6-iodobenzotrifluoride; 2-(Trifluoromethyl)-3-iodobenzonitrile; 3-Iodo-2-(trifluoromethyl)benzonitrile; 2-Trifluoromethyl-3-iodobenzonitrile; Benzonitrile, 3-iodo-2-(trifluoromethyl)-; 6-Iodo-2-(trifluoromethyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 3-Iodo-2-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC-MS for impurity profiling. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.