Description

4-Chloro-2-Trifluoromethoxynitrobenzene is a high-purity, specialized aromatic compound featuring a unique combination of chloro, nitro, and trifluoromethoxy substituents. This structure makes it a valuable and versatile advanced pharmaceutical intermediate and key building block for the synthesis of complex organic molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated and fluorinated aromatic cores.
• Agrochemical Synthesis: Serves as a key building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and advanced organic electronic materials due to its electron-withdrawing groups.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Nucleophilic Aromatic Substitution: The nitro and chloro groups make it reactive in SNAr reactions for introducing diverse functionalities.

Basic Information

Product Name	4-Chloro-2-Trifluoromethoxynitrobenzene
CAS No.	1261674-03-6
Molecular Formula	C7H3ClF3NO3
Molecular Weight	241.55 g/mol
Synonyms	1-Chloro-4-nitro-2-(trifluoromethoxy)benzene; 2-Trifluoromethoxy-4-chloronitrobenzene; 4-Chloro-2-(trifluoromethoxy)-1-nitrobenzene; 4-Chloro-α,α,α-trifluoro-2-nitroanisole; 2-Nitro-4-chlorophenyl trifluoromethyl ether; Benzene, 1-chloro-4-nitro-2-(trifluoromethoxy)-; 4-Chloro-2-(trifluoromethoxy)nitrobenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Trifluoromethoxynitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, NMR, and IR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for GMP-grade intermediate applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.