Description

4-Hydroxy-2-Trifluoromethoxy-Benzonitrile is a high-value fluorinated aromatic nitrile building block, distinguished by its trifluoromethoxy and hydroxy substituents. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling the development of advanced materials and active ingredients. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel compounds with enhanced biological activity and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of active pharmaceutical ingredients (APIs), particularly in creating molecules with improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to incorporate fluorinated aromatic units into specialty polymers, improving their chemical resistance, thermal stability, and optical properties.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new reactions and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	4-Hydroxy-2-Trifluoromethoxy-Benzonitrile
CAS No.	1261648-89-8
Molecular Formula	C8H4F3NO2
Molecular Weight	203.12 g/mol
Synonyms	2-Trifluoromethoxy-4-hydroxybenzonitrile; 4-Hydroxy-2-(trifluoromethoxy)benzonitrile; 2-(Trifluoromethoxy)-4-hydroxybenzonitrile; Benzonitrile, 4-hydroxy-2-(trifluoromethoxy)-; 4-Cyano-3-(trifluoromethoxy)phenol; 3-(Trifluoromethoxy)-4-hydroxybenzonitrile; 4-Hydroxy-α,α,α-trifluoro-o-toluonitrile
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2-Trifluoromethoxy-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is easily oxidized; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.