Description

1-Bromo-4-(Difluoromethyl)-2-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, difluoromethyl, and nitro substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and polymers with specific optical or electronic properties.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form new carbon-carbon bonds.
• Nitro Group Reduction & Functionalization: The nitro group can be selectively reduced to an amine, enabling further derivatization to amides, sulfonamides, or heterocycles.
• Fluorine Chemistry Exploration: An important reagent for studying the influence of the difluoromethyl (CF2H) group, a bioisostere for various functional groups, in medicinal chemistry.

Basic Information

Product Name	1-Bromo-4-(Difluoromethyl)-2-Nitrobenzene
CAS No.	1261614-43-0
Molecular Formula	C7H4BrF2NO2
Molecular Weight	252.02 g/mol
Synonyms	4-Bromo-3-nitrobenzylidene difluoride; 2-Nitro-4-bromobenzylidene difluoride; 4-Bromo-3-nitro-α,α-difluorotoluene; 1-Bromo-4-(difluoromethyl)-2-nitro-benzene; Benzene, 1-bromo-4-(difluoromethyl)-2-nitro-; α,α-Difluoro-4-bromo-3-nitrotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Difluoromethyl)-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.