Description

1-Chloro-3-Nitro-2-(Trifluoromethoxy)Benzene is a high-value, multi-functional aromatic building block characterized by its unique halogenated and nitro-substituted structure. This compound is critical for advanced organic synthesis, particularly in the development of complex molecules where the trifluoromethoxy group imparts desirable properties like enhanced metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group contributes to biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments due to its electron-withdrawing nitro and halogen substituents.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct biaryl systems common in many functional molecules.

Basic Information

Product Name	1-Chloro-3-Nitro-2-(Trifluoromethoxy)Benzene
CAS No.	1261570-83-5
Molecular Formula	C7H3ClF3NO3
Molecular Weight	241.55 g/mol
Synonyms	2-Chloro-6-nitro-1-(trifluoromethoxy)benzene; 1-Chloro-3-nitro-2-(trifluoromethoxy)benzene; Benzene, 1-chloro-3-nitro-2-(trifluoromethoxy)-; 2-(Trifluoromethoxy)-1-chloro-3-nitrobenzene; 3-Nitro-2-(trifluoromethoxy)chlorobenzene
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-3-Nitro-2-(Trifluoromethoxy)Benzene adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and MS, to verify identity and quantify impurities. Certificates of Analysis (COA) detailing all test results are provided with every shipment, and we support custom purity requirements for specific R&D or scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.