Description

3-Chloro-2,5-Difluorobenzonitrile is a high-purity, multi-functional aromatic nitrile building block distinguished by its unique halogen substitution pattern. This compound is critical for advanced organic synthesis, enabling the precise introduction of molecular complexity in target structures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro substituents modulate biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for high-performance electronic displays.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport materials and host materials in OLED device fabrication.
• Polymer Chemistry: Employed as a monomer or modifier to introduce aromatic, cyano, and halogen functionalities into specialty polymers, enhancing thermal and chemical resistance.
• Chemical Research & Development: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution in academic and industrial R&D settings.

Basic Information

Item	Details
Product Name	3-Chloro-2,5-Difluorobenzonitrile
CAS No.	1261561-88-9
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	2,5-Difluoro-3-chlorobenzonitrile; 3-Chloro-2,5-difluorobenzene carbonitrile; Benzonitrile, 3-chloro-2,5-difluoro-; 1261561-88-9; 3-Chloro-2,5-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2,5-Difluorobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.