Description

2-Chloro-1-(Difluoromethoxy)-3-Nitro-Benzene is a specialized aromatic compound featuring a unique difluoromethoxy substituent, making it a valuable fluorinated building block for advanced chemical synthesis. Its molecular structure is engineered to introduce both fluorine atoms and a nitro group into target molecules, which is critical for modulating the physical, chemical, and biological properties of final products. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key fluorinated synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for developing specialty polymers and liquid crystals that require fluorinated aromatic units for specific performance characteristics.
• Organic Synthesis Building Block: Employed in cross-coupling reactions and nucleophilic aromatic substitutions to construct complex, multi-functional aromatic systems in academic and industrial labs.

Basic Information

Product Name	2-Chloro-1-(Difluoromethoxy)-3-Nitro-Benzene
CAS No.	1261523-28-7
Molecular Formula	C7H4ClF2NO3
Molecular Weight	223.56 g/mol
Synonyms	1-Chloro-2-(difluoromethoxy)-3-nitrobenzene; 3-Nitro-2-chlorophenyl difluoromethyl ether; 2-Chloro-α,α-difluoro-3-nitroanisole; Benzene, 2-chloro-1-(difluoromethoxy)-3-nitro-; 2-Chloro-3-nitro-α,α-difluoroanisole; 2-Chloro-3-nitrophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-1-(Difluoromethoxy)-3-Nitro-Benzene is manufactured under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.