Description

2-(Difluoromethyl)-6-Fluorobenzonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique difluoromethyl and fluorine substituents make it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and electronic materials requiring specific dielectric properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitution reactions to construct complex, fluorinated molecular architectures.
• Chemical Biology & Medicinal Chemistry: Utilized in the design and synthesis of molecular probes and tool compounds for target validation and mechanism-of-action studies.

Basic Information

Item	Details
Product Name	2-(Difluoromethyl)-6-Fluorobenzonitrile
CAS No.	1261442-19-6
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	6-Fluoro-2-(difluoromethyl)benzonitrile; 2,6-Difluorobenzylidene Cyanide (derivative); 2-(Difluoromethyl)-6-fluorophenyl cyanide; α,α-Difluoro-6-fluoro-o-tolunitrile; 2-(Difluoromethyl)-6-fluorobenzene carbonitrile; 1261442-19-6; 2,6-Difluorobenzonitrile, difluoromethyl-
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)-6-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.