Description

2-Amino-4-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its trifluoromethoxy and amino substituents. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Serves as a versatile building block for creating novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers due to its electron-withdrawing nitrile and fluorine-containing groups.
• Fluorescent Dye and Sensor Chemistry: Acts as a core structure for synthesizing specialized fluorophores and molecular sensors used in bio-imaging and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Amino-4-(Trifluoromethoxy)Benzonitrile
CAS No.	1260847-67-3
Molecular Formula	C8H5F3N2O
Molecular Weight	202.14 g/mol
Synonyms	4-(Trifluoromethoxy)-2-aminobenzonitrile; 2-Amino-4-(trifluoromethoxy)benzonitrile; 2-Cyano-5-(trifluoromethoxy)aniline; Benzonitrile, 2-amino-4-(trifluoromethoxy)-; 5-Amino-2-(trifluoromethoxy)benzonitrile; 2-Amino-α,α,α-trifluoro-p-anisonitrile
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(Trifluoromethoxy)Benzonitrile is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.