Description

5-Chloro-3-Fluoro-2-Methoxynitrobenzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of fluorinated and chlorinated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Employed in the synthesis of complex, high-performance dyes and pigments due to its nitro and methoxy functional groups.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, enabling rapid diversification of chemical libraries.

Basic Information

Product Name	5-Chloro-3-Fluoro-2-Methoxynitrobenzene
CAS No.	1260845-62-2
Molecular Formula	C7H5ClFNO3
Molecular Weight	205.57 g/mol
Synonyms	1-Chloro-5-fluoro-2-methoxy-3-nitrobenzene; 3-Nitro-5-chloro-2-fluoroanisole; 2-Methoxy-5-chloro-3-fluoronitrobenzene; 5-Chloro-3-fluoro-2-methoxy-1-nitrobenzene; 2-Chloro-6-fluoro-3-methoxynitrobenzene (isomer reference); Benzene, 1-chloro-5-fluoro-2-methoxy-3-nitro-; CFMNB (abbreviation)
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Fluoro-2-Methoxynitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.