Description

1-(2,6-Difluorophenyl)Cyclobutane-1-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutane ring and a difluorophenyl moiety. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific molecular geometry and fluorine substitution. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of next-generation small-molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the difluorophenyl group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty chemicals and functional materials, including liquid crystals and organic semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	1-(2,6-Difluorophenyl)Cyclobutane-1-Carbonitrile
CAS No.	1260741-00-1
Molecular Formula	C11H9F2N
Molecular Weight	193.19 g/mol
Synonyms	1-(2,6-Difluorophenyl)cyclobutanecarbonitrile; Cyclobutanecarbonitrile, 1-(2,6-difluorophenyl)-; 2,6-Difluoro-α-(1-cyanocyclobutyl)benzene; 1-(2,6-Difluorophenyl)-1-cyclobutanecarbonitrile; 1-Cyano-1-(2,6-difluorophenyl)cyclobutane
EINECS	Contact for details

Quality Control

Our 1-(2,6-Difluorophenyl)Cyclobutane-1-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.