Description

Fmoc-2-Fluoro-L-Homophenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing fluorinated aromatic side chains into peptide chains, enabling the fine-tuning of biological activity, metabolic stability, and binding affinity. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, used to incorporate a fluorinated homophenylalanine residue.
• Pharmaceutical Research & Development: Synthesis of peptide drug candidates where fluorine substitution is used to enhance potency, improve pharmacokinetic profiles, or serve as a positron emission tomography (PET) tracer label.
• Chemical Biology & Proteomics: Construction of peptide libraries and probes for studying protein-protein interactions and enzyme activity.
• Agrochemical Research: Development of novel bioactive peptides with potential applications in crop protection.
• Material Science: Synthesis of specialized fluorinated peptides for creating advanced biomaterials and surface coatings.

Basic Information

Product Name	Fmoc-2-Fluoro-L-Homophenylalanine
CAS No.	1260587-53-8
Molecular Formula	C25H22FNO4
Molecular Weight	419.45 g/mol
Synonyms	Fmoc-2-Fluoro-L-homoPhe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-fluoro-L-homophenylalanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(2-fluorophenyl)butanoic acid; Fmoc-L-2-Fluorohomophenylalanine; Fmoc-2-F-homoPhe-OH; Nα-Fmoc-2-fluoro-L-homophenylalanine; Fmoc-2-Fluoro-DL-Homophenylalanine (mixture); Boc-2-Fluoro-L-Homophenylalanine (related Boc-protected variant)
EINECS	Contact for details

Quality Control

Our Fmoc-2-Fluoro-L-Homophenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and NMR for structural confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.