Description

3-Bromo-5-Fluoro-2-Methoxybenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and methoxy substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Serves as a crucial building block for creating advanced herbicides, fungicides, and insecticides, where the fluorine and bromine atoms can enhance biological activity and environmental stability.
• Material Science Precursor: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify molecular conformation and intermolecular interactions.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification of molecular scaffolds.
• Fluorinated Compound Library: An essential starting material for generating libraries of fluorinated compounds in medicinal chemistry to improve metabolic stability and membrane permeability.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	3-Bromo-5-Fluoro-2-Methoxybenzonitrile
CAS No.	1260022-38-5
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	2-Bromo-6-Fluoro-3-Methoxybenzonitrile; 5-Fluoro-3-Bromo-2-Methoxybenzonitrile; Benzonitrile, 3-bromo-5-fluoro-2-methoxy-; 2-Methoxy-3-bromo-5-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoro-2-Methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.